Ashwagandha Sensoril
Root + leaf ashwagandha extract standardized to ~10% withanolides, licensed by Natreon (US-based), and the substrate of the strongest sleep + anxiety trials in the ashwagandha literature. | Compound
Aliases (4)
▸ Overview TL;DR
Root + leaf ashwagandha extract standardized to ~10% withanolides, licensed by Natreon (US-based), and the substrate of the strongest sleep + anxiety trials in the ashwagandha literature. Higher withaferin A content than KSM-66 (from leaf inclusion) — more sedating, more anxiolytic-skewed, slightly higher autoimmune-flare risk (theoretical). For Dylan: OPTIONAL-ADD low priority — V4 sleep stack is robust; KSM-66 better fits Dylan's AM-friendly profile if any ashwagandha is added. Parent file ashwagandha.md has full pharmacology — this file focuses on Sensoril-specific differences.
▸ Mechanism of action
Same general mechanism as parent. Sensoril-specific notes:
- Root + leaf extraction: Includes leaf material → higher withaferin A (the more potent and more cytotoxic withanolide). Withaferin A is a known immunomodulator and Nrf2 activator.
- ~10% withanolide standardization: Higher concentration than KSM-66's ~5%, allowing lower mg dosing.
- Sleep + anxiolysis dominance: The withaferin A enrichment and overall higher withanolide load skew the subjective and biomarker profile toward sedation and anxiolysis.
- Pharmacokinetics: Similar withanolide A peak/half-life to KSM-66.
▸ Pharmacokinetics No data
▸ What to expect Generic
- 1Week 1Tolerability and dose-response.
- 2Week 2-4Early effect window.
- 3Week 4-8Peak benefit assessment.
- 4Week 8+Cycle decision point.
▸ Side effects + safety
Same as parent. Sensoril-specific notes:
- Higher withaferin A → slightly higher theoretical autoimmune flare risk; case reports rare but Sensoril-associated
- Daytime drowsiness if dosed AM
- Hepatotoxicity case reports more often associated with Sensoril than KSM-66 (still rare; possibly publication bias from Sensoril's earlier market presence)
- "Vivid dreams" common at higher PM doses
▸Interactions6 compounds
- l-tryptophan / glycine (sleep stack):SynergisticCompound sleep-architecture support — but Dylan already has these
- magnesium-glycinateSynergistic(Dylan's V4): GABAergic + Mg synergy
- rhodiolaSynergistic(Dylan's V4): AM-rhodiola + PM-Sensoril is a sensible adaptogen split
- l-theanineSynergistic(Dylan's V4): Additive evening calm
- Other sedativesAvoid(benzos, alcohol, high-dose THC, melatonin >5 mg): Compound sedation
- Thyroid hormone replacement, immunosuppressantsAvoidsee parent