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Overview
What is Adipotide (Prohibitin‑TP01)?
Adipotide (Prohibitin‑TP01) is a chimeric, adipose‑vasculature–targeted peptidomimetic that homes to prohibitin/annexin A2 on white adipose tissue endothelium and delivers a pro‑apoptotic D‑(KLAKLAK)2 motif. In obese primates it produced rapid fat loss with improved insulin resistance, but development halted after an early Phase 1 oncology trial; kidney safety signals (reversible proximal tubule changes) remain a key concern.
Key Benefits
Rapid fat‑mass reduction in obese non‑human primates with improved insulin sensitivity; direct WAT vascular targeting.
Mechanism of Action
CKGGRAKDC homes to prohibitin/annexin A2 on white‑fat endothelium; the linked D‑(KLAKLAK)2 disrupts mitochondrial membranes after internalization, triggering localized endothelial apoptosis and adipocyte loss.
Research Indications
Adipose Mass Reduction
Selective WAT vascular targeting produced 7–15% body‑weight loss over 4 weeks in obese macaques.
Research Protocols
Disclaimer
These are commonly discussed research protocols and not medical advice. Consult a healthcare provider before use.
Timing
Rotate SC sites to reduce irritation; ensure adequate hydration and frequent renal labs during treatment.
Peptide Interactions
How to Reconstitute
Important
Always use bacteriostatic water (BAC). Sterile technique is essential.
Sanitize hands and workspace; swab vial septum.
Inject BAC water slowly down the vial wall; do not jet onto powder.
Gently swirl until fully dissolved (do not shake).
Label with concentration/date; store at 2–8°C; discard per lab SOP.
Quality Indicators
Intact Lyophilized Cake
White, uniform ‘cake’ indicates proper lyophilization.
Clear Solution
Fully dissolved, particle‑free solution after reconstitution.
Minor Clumping
Small clumps may form from shipping; should fully dissolve with gentle swirl.
Collapsed/Moist Cake
Suggests temperature excursion; do not use without QC.
Cloudiness/Precipitate
Indicates degradation or contamination—discard per SOP.
What to Expect
- Week 1–2: Early reduction in abdominal circumference
- Week 2–4: Progressive weight/fat‑mass decline
- Recovery: Partial rebound possible after discontinuation
- Common lab signals: mild creatinine rise, electrolyte shifts
Side Effects & Safety
- Not FDA‑approved; investigational/educational only.
- Monitor serum creatinine, BUN, urinalysis, electrolytes weekly in animal studies.
- Kidney: dose‑dependent, largely reversible proximal tubule changes observed in primates.
- Avoid dehydration; consider temporarily pausing if creatinine rises persistently.
- Pregnancy/lactation: not studied; avoid.
References
Human adipose targeting – imaging validation (2018)
Molecular MRI using CKGGRAKDC confirmed prohibitin‑based adipose targeting, supporting the translational targeting concept.
View Study (opens in new tab) →Obese rhesus macaques – fixed‑dose efficacy & safety (2011)
White‑adipose vasculature targeting led to rapid fat mass reduction and improved insulin dynamics. Kidney signals (creatinine rise, tubular changes) were dose‑related and largely reversible after discontinuation.
View Study (opens in new tab) →Rhesus macaques – dose‑finding (2011)
Identified 0.43 mg/kg SC daily as the optimal primate dose balancing efficacy and renal safety for subsequent fixed‑dose testing.
View Study (opens in new tab) →Quick Start Guide
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